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​​In this presentation Stephen will briefly explain his postmortem study, and show that such a study is both feasible and acceptable in this setting.  He will then present “case studies” from deceased TB patients dying on Ward at Mulago National Referral Hospital, where he has isolated individual granulomas and used multi parameter confocal imaging to describe several different lesions identified from our postmortem cohort. 

Speaker

Dr Stephen Cose, LSHTM

Stephen’s current research applies his expertise in fundamental cellular immunology to the investigation of tuberculosis in Uganda, a setting in which this disease is still highly endemic. In his previous posts Stephen undertook research into lymphocyte migration and trafficking, studies which were performed in mice and gave him key skills in isolating lymphocytes from tissues, multiparameter flow cytometry and immunofluorescence techniques. Since moving to Uganda Stephen’s focus has now changed to human Immunology. Previous studies have included an MRC funded project to look at whether a latent TB infection in mothers affects their infant’s response to BCG. This is an important area of research as BCG is not as protective in settings such as Uganda, and this project aimed to understand why this may be the case. Other completed studies were the non-specific effects of BCG immunisation, where he conducted a delayed BCG trial to examine whether BCG has non-specific beneficial effects in healthy newborns. Stephen have a major interest in the role that B cells play in Mycobacterium tuberculosis (M.tb) infection, and TB disease in pregnancy.  His current primary research focus is examining tissue-specific responses to TB in a human TB postmortem cohort. 

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