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Since joining the MRC Unit in 2006, my research has focused on immunity to tuberculosis, with a particular emphasis on discovery and validation of biomarkers for prognosis, diagnosis, and treatment response. The BMGF-funded TB biomarker study has generated multiple publications including the key publication in AJRCCM for which I was second author (Suliman et al., 2018); The Lancet (Zak et al., 2016), Plos Medicine (Penn-Nicholson et al, 2020) and Nature communications (Weiner et al., 2019). More recently I have focused on analysis of early protective immunity to Mtb (Weiner et al., CID, 2020; Sutherland JS, senior author), treatment response biomarkers (LSHTM MSc project 2019; Vickers et al., 2020; Sutherland JS, senior author) and Neutrophils in TB lung pathology (PhD student, Muefong et al., 2020 and 2021; Sutherland JS, senior author). Current research projects in my laboratory include elucidating the risk factors for long-term lung pathology in TB; defining the role of non-classical T cells, B cells and antibodies in the early response to Mtb infection; defining correlates of risk for progression to active TB; understanding immunity at the site of infection; immunity to TB in the context of HIV and other co-infections (including Influenza) and development of rapid diagnostic tests for TB.