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Dr Christian Bottomley

Associate Professor

United Kingdom

I joined the International Statistics and Epidemiology Group at LSHTM in 2008. Prior to joining LSHTM, I completed a PhD in mathematical biology at University College London (UCL) and worked as a medical statistician in the Department of Primary Care and Population Sciences, also at UCL.

Affiliations

Department of Infectious Disease Epidemiology and International Health
Faculty of Epidemiology and Population Health

Centres

Centre for Data and Statistical Science for Health
Centre for Evaluation
TB Centre
Antimicrobial Resistance Centre

Teaching

I am a course organiser for the module Design and Analysis of Epidemiological Studies, and also a tutor on the Epidemiology MSc and Clinical Trials MSc.

Research

I am statistician and infectious disease epidemiologist. My research centres around the evaluation of vaccines and other public health interventions aimed at reducing the burden of infectious disease among children in low-and-middle-income countries. I am also interested in the development of statistical methods, particularly around the analysis of time series data for evaluating population-level interventions.

I collaborate with researchers at various institutions, including the MRC Gambia, the KEMRI-Wellcome Trust Research Programme in Kenya, and more recently, the Biomedical Research and Training Institute (BRTI) in Zimbabwe.

Recently completed studies for which I was the principal statistician include:

• PregnAnZI-2: A trial evaluating the effectiveness of azithromycin, administered during labour, for preventing sepsis in newborns in The Gambia
• A trial of fractional doses of pneumococcal vaccines in Kenya

Ongoing studies for which I am the principal statistician include:

• IMPRESS: a cluster-randomised trial of a hospital management intervention in Malawi
• FIEBRE: a multi-country study investigating the causes of fever in children and adults
• SAVIS: a phase 1 trial of a vaccine against non-typhoidal Salmonella
• An evaluation of RajPusht - a complex intervention centred around a cash transfer programme for pregnant women in Rajasthan, India

Selected Publications

ROCA, A; CAMARA, B; Bognini, JD; Nakakana, UN; Somé, AM; Beloum, N; Rouamba, T; Sillah, F; Danso, M; Jones, JC; Graves, S; Jagne, I; Getanda, P; DARBOE, S; Tahita, MC; Ndure, E; Franck, HS; Edmond, SY; Dondeh, BL; Nassa, WG J; Garba, Z; BOJANG, A; Njie, Y; BOTTOMLEY, C; Tinto, H; ... PregnAnZI-2 Working Group,
2023
JAMA
BOTTOMLEY, C; OOKO, M; GASPARRINI, A; KEOGH, RH;
2023
Statistics in medicine
BOTTOMLEY, C; OTIENDE, M; Uyoga, S; GALLAGHER, K; Kagucia, EW; Etyang, AO; Mugo, D; Gitonga, J; Karanja, H; Nyagwange, J; ADETIFA, IM O; AGWEYU, A; Nokes, DJ; Warimwe, GM; SCOTT, JA G;
2021
Nature communications
BOTTOMLEY, C; SCOTT, JA G; Isham, V;
2019
Epidemiologic Methods
Silaba, M; OOKO, M; BOTTOMLEY, C; Sande, J; Benamore, R; Park, K; Ignas, J; Maitland, K; Mturi, N; Makumi, A; OTIENDE, M; Kagwanja, S; Safari, S; Ochola, V; Bwanaali, T; Bauni, E; Gleeson, F; Deloria Knoll, M; ADETIFA, I; Marsh, K; Williams, TN; Kamau, T; Sharif, S; Levine, OS; Hammitt, LL; ... SCOTT, JA G.
2019
The Lancet Global Health
USUF, E; BOTTOMLEY, C; Bojang, E; Cox, I; BOJANG, A; Gladstone, R; KAMPMANN, B; Hill, PC; ROCA, A;
2018
Clinical infectious diseases
MARKS, M; Mitjà, O; BOTTOMLEY, C; Kwakye, C; Houinei, W; Bauri, M; Adwere, P; Abdulai, AA; Dua, F; Boateng, L; Wangi, J; Ohene, S-A; Wangnapi, R; Simpson, SV; Miag, H; Addo, KK; Basing, LA; Danavall, D; Chi, KH; Pillay, A; Ballard, R; Solomon, AW; Chen, CY; Bieb, SV; Adu-Sarkodie, Y; ... Study team,
2018
The Lancet Global health
TUSTING, LS; BOTTOMLEY, C; Gibson, H; KLEINSCHMIDT, I; Tatem, AJ; Lindsay, SW; Gething, PW;
2017
PLoS medicine
BOTTOMLEY, C; Isham, V; Vivas-Martínez, S; Kuesel, AC; Attah, SK; Opoku, NO; Lustigman, S; Walker, M; Basáñez, M-G;
2016
Parasites & vectors
ROCA, A; Oluwalana, C; BOJANG, A; CAMARA, B; KAMPMANN, B; BAILEY, R; Demba, A; BOTTOMLEY, C; D'ALESSANDRO, U;
2016
Clinical microbiology and infection